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Gary K Schwartz Selected Research

sotrastaurin

11/2021A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma.
1/2020Genomic Profiling of Metastatic Uveal Melanoma and Clinical Results of a Phase I Study of the Protein Kinase C Inhibitor AEB071.
5/2014The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.

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Gary K Schwartz Research Topics

Disease

101Neoplasms (Cancer)
01/2022 - 02/2002
36Sarcoma (Soft Tissue Sarcoma)
04/2022 - 04/2005
24Uveal melanoma
01/2022 - 04/2011
22Melanoma (Melanoma, Malignant)
01/2022 - 04/2010
14Liposarcoma
01/2022 - 07/2007
10Neoplasm Metastasis (Metastasis)
01/2022 - 12/2002
9Fatigue
01/2022 - 05/2005
9Neutropenia
01/2020 - 04/2002
7Neurofibrosarcoma (MPNST)
10/2021 - 04/2008
7Colonic Neoplasms (Colon Cancer)
03/2011 - 07/2002
6Nausea
01/2022 - 10/2008
6Breast Neoplasms (Breast Cancer)
01/2020 - 01/2007
6Disease Progression
12/2018 - 11/2006
6Colorectal Neoplasms (Colorectal Cancer)
11/2010 - 03/2004
5Synovial Sarcoma (Synovioma)
01/2019 - 09/2012
5Diarrhea
12/2018 - 05/2005
4Vomiting
10/2016 - 10/2008
4Polyploidy
03/2016 - 03/2009
3Squamous Cell Carcinoma of Head and Neck
02/2021 - 02/2002
3Carcinogenesis
02/2021 - 01/2009
3Leiomyosarcoma
12/2020 - 11/2018
3Ewing Sarcoma (Sarcoma, Ewing)
07/2020 - 12/2011
3Hypertension (High Blood Pressure)
12/2018 - 11/2006
3Exanthema (Rash)
12/2018 - 04/2016
3Carcinoma (Carcinomatosis)
04/2016 - 08/2005
3Hemangiosarcoma (Angiosarcoma)
03/2015 - 07/2009
3Stomach Neoplasms (Stomach Cancer)
04/2009 - 06/2003
3Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2009 - 12/2003
2Chondrosarcoma
12/2021 - 09/2013
2Fibrosarcoma
11/2021 - 04/2013
2Dehydration (Water Stress)
10/2021 - 01/2018
2Infections
01/2021 - 01/2009
2COVID-19
01/2021 - 10/2020
2Pancreatic Neoplasms (Pancreatic Cancer)
12/2020 - 01/2009

Drug/Important Bio-Agent (IBA)

16Irinotecan (Camptosar)FDA LinkGeneric
11/2012 - 07/2002
14alvocidib (flavopiridol)IBA
11/2012 - 04/2002
13Pharmaceutical PreparationsIBA
10/2020 - 07/2007
12Phosphotransferases (Kinase)IBA
01/2022 - 12/2006
12DNA (Deoxyribonucleic Acid)IBA
12/2021 - 07/2005
9Proteins (Proteins, Gene)FDA Link
10/2020 - 04/2011
9Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
03/2017 - 04/2008
8Imatinib Mesylate (Gleevec)FDA Link
11/2018 - 06/2006
8AZD 6244IBA
01/2018 - 01/2012
8Cyclin-Dependent Kinases (cdk Proteins)IBA
05/2012 - 04/2002
7Dacarbazine (DIC)FDA LinkGeneric
01/2020 - 06/2014
6palbociclibIBA
01/2020 - 01/2012
5Sirolimus (Rapamycin)FDA Link
10/2021 - 10/2010
5Temozolomide (Temodar)FDA LinkGeneric
12/2020 - 04/2013
5Sorafenib (BAY 43-9006)FDA Link
01/2019 - 08/2007
5IpilimumabIBA
01/2018 - 04/2010
5Mitogen-Activated Protein KinasesIBA
09/2017 - 04/2008
5Docetaxel (Taxotere)FDA Link
03/2016 - 06/2003
5Fluorouracil (Carac)FDA LinkGeneric
12/2009 - 03/2004
4Biomarkers (Surrogate Marker)IBA
04/2022 - 11/2011
4Immune Checkpoint InhibitorsIBA
12/2021 - 10/2018
4Paclitaxel (Taxol)FDA LinkGeneric
01/2021 - 04/2002
4Protein Kinase CIBA
01/2020 - 03/2005
4GTP-Binding Proteins (G-Protein)IBA
07/2019 - 07/2012
4Adenosine Triphosphate (ATP)IBA
09/2017 - 01/2012
4Cyclin-Dependent Kinase 4IBA
01/2017 - 01/2012
4Doxorubicin (Adriamycin)FDA LinkGeneric
07/2016 - 10/2005
4Small Interfering RNA (siRNA)IBA
01/2015 - 04/2009
4Checkpoint Kinase 1IBA
09/2014 - 04/2007
42- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphateIBA
04/2013 - 03/2009
3selinexorIBA
01/2022 - 10/2016
3RNA (Ribonucleic Acid)IBA
01/2022 - 08/2015
3sotrastaurinIBA
11/2021 - 05/2014
3Aspartate Aminotransferases (Aspartate Transaminase)IBA
10/2021 - 11/2015
3Alanine Transaminase (SGPT)IBA
10/2021 - 11/2015
3Biological ProductsIBA
02/2021 - 07/2007
3Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
01/2021 - 02/2002
3TensinsIBA
10/2020 - 04/2011
3IGF Type 1 Receptor (IGF 1 Receptor)IBA
07/2020 - 04/2011
3Retinoblastoma ProteinIBA
01/2020 - 01/2012
3tyrosine receptor (receptor, tyrosine)IBA
11/2018 - 01/2016
3AntigensIBA
10/2018 - 01/2013
3TOR Serine-Threonine KinasesIBA
09/2017 - 01/2012
3Insulin-Like PeptidesIBA
04/2016 - 04/2011
3TrabectedinIBA
03/2016 - 01/2015
3GemcitabineFDA Link
03/2016 - 01/2015
3Bevacizumab (Avastin)FDA Link
01/2015 - 10/2005
3Cisplatin (Platino)FDA LinkGeneric
04/2011 - 11/2006
3PoisonsIBA
01/2009 - 09/2004
3Type I DNA Topoisomerases (Topoisomerase I)IBA
01/2009 - 09/2004
2Cyclin DIBA
04/2022 - 09/2017
22,2- dimethyl- N- (6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- N'- (2,2,3,3,3- pentafluoropropyl)malonamideIBA
01/2022 - 04/2013
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2022 - 10/2015
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2022 - 04/2013
2VorinostatFDA Link
12/2021 - 10/2011
2EnzymesIBA
12/2021 - 02/2018
2AlpelisibIBA
11/2021 - 05/2014
2pexidartinibIBA
10/2021 - 06/2014
2Poly(ADP-ribose) Polymerase InhibitorsIBA
01/2021 - 12/2020
2Alkylating AgentsIBA
12/2020 - 11/2018
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
10/2020 - 04/2013

Therapy/Procedure

62Therapeutics
04/2022 - 12/2002
34Drug Therapy (Chemotherapy)
12/2021 - 12/2002
5Immunotherapy
12/2020 - 05/2013
4Radiotherapy
12/2021 - 12/2002
2Chemoradiotherapy
01/2021 - 04/2009